Cohort Studyhigh evidence
How infection affects the relationship between leukocyte count and mortality risk in intensive care.
Infection·May 18, 2026·PMID 42149358
Why it mattersLeukocyte count is a ubiquitous and inexpensive biomarker in ICU prognostic models, but its interpretation may be confounded by the underlying diagnosis. This study clarifies that leukocytosis should not be viewed as a uniform marker of severity in all critically ill patients, potentially refining risk stratification and avoiding misclassification in those admitted with infection.
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