Meta-Analysishigh evidence
Impact of creatine supplementation on kidney health: a systematic review and meta-analysis.
International urology and nephrology·July 27, 2026·PMID 42507286
Why it mattersClinicians in supplements, nutrition, and performance longevity frequently encounter concerns about creatine's renal safety. This meta-analysis provides reassurance that creatine-induced rises in serum creatinine and drops in eGFR are likely due to increased creatinine production, not nephrotoxicity, as confirmed by unchanged Cr-EDTA GFR.
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