Systematic Reviewhigh evidence
Comparative effectiveness and safety of pharmacological interventions for sleep outcomes in chronic non-cancer pain: a systematic review and network meta-analysis.
Sleep medicine reviews·July 10, 2026·PMID 42430948
Why it mattersSleep disturbances in chronic pain patients worsen outcomes, yet comparative safety and efficacy of sleep-targeting medications are unclear. This analysis identifies melatonin as a potentially safer, effective option, while highlighting the unfavorable risk-benefit profiles of commonly used agents like opioids and gabapentinoids.
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