Randomized Trialhigh evidence

Cerebral Hemodynamic and Metabolic Responses to Anesthesia and Vasopressors in Adult Shoulder Surgery: a 2x2 Factorial Design Randomized Controlled Trial with Light-based Neuromonitoring (CHEM-FACT study).

Anesthesiology·July 16, 2026·PMID 42479502

Why it matters

Cerebral desaturation during beach chair positioning can contribute to adverse neurological outcomes. Understanding how vasopressor choice influences cerebral oxygenation and metabolism over time may guide intraoperative hemodynamic management to optimize brain perfusion.

Infographic summary of Cerebral Hemodynamic and Metabolic Responses to Anesthesia and Vasopressors in Adult Shoulder Surgery: a 2x2 Factorial Design Randomized Controlled Trial with Light-based Neuromonitoring (CHEM-FACT study).
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