Randomized Trialhigh evidence
Effects of vaginal dehydroepiandrosterone and estradiol on dyspareunia, a symptom of vulvovaginal atrophy in postmenopausal women - a randomized controlled trial.
Maturitas·May 1, 2026·PMID 41903372
Why it mattersDyspareunia from vulvovaginal atrophy is common and undertreated. This trial suggests vaginal DHEA may offer greater symptom relief, especially for severe pain, while estradiol may better restore tissue health. Clinicians managing menopause-related sexual dysfunction can use these data to tailor therapy.
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