Cohort Studyhigh evidence
Metabolomic and Proteomic Signatures of Cardiorespiratory Fitness for Predicting All-Cause Mortality and Non-Communicable Disease Risk: A Prospective Study in the UK Biobank.
Circulation. Genomic and precision medicine·July 3, 2026·PMID 42394615
Why it mattersThese molecular signatures provide objective, blood-based proxies for CRF that predict hard outcomes, offering clinicians a tool to assess fitness-related risk beyond self-report or exercise testing, and highlighting biological pathways that may mediate the benefits of exercise.
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