Cohort Studymoderate evidence
The human gut microbiome primes fever after vaccination.
Science (New York, N.Y.)·October 8, 2026·PMID 42848888
Why it mattersVaccine-induced fever contributes to hesitancy and reduced uptake. Identifying a modifiable gut microbiome driver of fever risk offers a potential strategy to improve vaccine tolerability through diet or microbiome-targeting interventions, relevant for clinicians advising patients on vaccination and managing side effects.
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