Randomized Trialhigh evidence
YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism in Patients With Cancer: A Randomized Clinical Trial.
JAMA·July 12, 2026·PMID 42437322
Why it mattersCurrent guidelines recommend direct CTPA for suspected PE in cancer patients due to limited evidence for D-dimer–based algorithms. This trial provides robust evidence that the YEARS algorithm is safe and reduces imaging, potentially decreasing radiation exposure, contrast load, and ED length of stay in this high-risk population.
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