Randomized Trialhigh evidence
Tenecteplase for Acute Non-Large Vessel Occlusion 4.5 to 24 Hours After Ischemic Stroke: The OPTION Randomized Clinical Trial.
JAMA·April 7, 2026·PMID 41642827
Why it mattersThis trial provides evidence that tenecteplase may extend the treatment window for non-large vessel occlusion stroke up to 24 hours in selected patients with salvageable tissue, a population currently without proven acute reperfusion therapy.
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