Randomized Trialhigh evidence
Effect of diet macronutrient content on the cardiometabolic response to weight loss: A randomized clinical trial.
Cell metabolism·August 27, 2026·PMID 42660124
Why it mattersFor patients with prediabetes and hepatic steatosis, the macronutrient composition of a weight-loss diet may influence hepatic metabolic improvements beyond weight loss alone. A very-low-carbohydrate approach could offer greater hepatic and glycemic benefits, informing personalized dietary recommendations for cardiometabolic risk reduction.
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