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Testosterone Replacement Therapy Is Associated with Extensor Mechanism Disruption after Total Knee Arthroplasty.
The journal of knee surgery·May 1, 2026·PMID 41224231
Why it mattersKnee extensor mechanism disruption after TKA is a devastating complication with high morbidity. Identifying modifiable risk factors like TRT use allows orthopaedic surgeons to better counsel patients preoperatively and potentially mitigate risk.

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