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Testosterone Replacement Therapy Is Associated with Extensor Mechanism Disruption after Total Knee Arthroplasty.

The journal of knee surgery·May 1, 2026·PMID 41224231

Why it matters

Knee extensor mechanism disruption after TKA is a devastating complication with high morbidity. Identifying modifiable risk factors like TRT use allows orthopaedic surgeons to better counsel patients preoperatively and potentially mitigate risk.

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