Meta-Analysishigh evidence
Comparative efficacy and safety of hydrocortisone-based regimens in septic shock: A network meta-analysis.
Journal of critical care·September 22, 2026·PMID 42784878
Why it mattersCorticosteroid dosing and combination therapy in septic shock remain debated. This analysis suggests higher-dose hydrocortisone improves survival but raises infection risk, whereas adding fludrocortisone may enhance benefit without added harm, informing regimen selection in critical care.
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