Randomized Trialhigh evidence

Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial.

Nature aging·March 1, 2025·PMID 39900648

Why it matters

This is among the first large RCTs to test whether common, low-cost interventions can slow epigenetic aging, providing clinicians with evidence on practical strategies that may influence biological age beyond chronological time.

Infographic summary of Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial.
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