Randomized Trialhigh evidence
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial.
Nature aging·March 1, 2025·PMID 39900648
Why it mattersThis is among the first large RCTs to test whether common, low-cost interventions can slow epigenetic aging, providing clinicians with evidence on practical strategies that may influence biological age beyond chronological time.

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