Randomized Trialhigh evidence
Acetaminophen (Paracetamol) or Opioid Plus Ibuprofen for Children's Musculoskeletal Injury.
JAMA·May 20, 2026·PMID 42160043
Why it mattersOpioid stewardship is critical in pediatric pain management. This study provides direct evidence that a non-opioid regimen can match opioid-containing analgesia for acute musculoskeletal injury, helping clinicians avoid opioid risks while maintaining effective pain control.
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