Basic Sciencemoderate evidence
Caloric restriction modulates genome-wide somatic mutation in mice.
Cell·September 9, 2026·PMID 42716011
Why it mattersSomatic mutation accumulation is a hallmark of aging, and this study provides direct evidence that caloric restriction—a known lifespan-extending intervention—reduces mutation burden in multiple tissues. For clinicians focused on longevity and biological aging, this establishes genomic integrity as a modifiable axis of aging and suggests a mechanistic link between diet and age-related disease risk.
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