Randomized Trialhigh evidence

Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea.

The New England journal of medicine·October 21, 2026·PMID 42904878

Why it matters

OSA in patients with obesity is common and often undertreated; current therapies like CPAP have adherence challenges. Retatrutide, a triple agonist, offers a potential pharmacologic option that addresses both weight and AHI, with clinically meaningful reductions in sleep apnea severity.

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