Randomized Trialhigh evidence
Short or Long Antibiotic Regimens in Orthopedics.
The New England journal of medicine·September 16, 2026·PMID 42748421
Why it mattersOrthopedic infections often require prolonged systemic antibiotics, which carry risks of adverse effects, drug interactions, and antimicrobial resistance. This trial provides high-level evidence that a short course may be as effective as a long course when local antibiotics are used, potentially reducing treatment burden and complications.
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