Meta-Analysishigh evidence
Safety profile comparison of intra-articular corticosteroids, hyaluronic acid, platelet-rich plasma, and cell-based injections for knee osteoarthritis: A systematic review and meta-analysis by the ESSKA Orthobiologics Initiative.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·December 26, 2025·PMID 41451630
Why it mattersInjection safety is a key factor in treatment selection for knee OA. This large-scale comparison provides relative risk estimates that can inform shared decision-making and patient counseling about expected adverse event profiles.
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