Randomized Trialhigh evidence

Psilocybin in the Treatment of Cocaine Use Disorder: A Randomized Clinical Trial.

JAMA network open·May 1, 2026·PMID 42096204

Why it matters

Cocaine use disorder lacks approved pharmacotherapies. This trial provides early evidence that psilocybin-assisted therapy may offer a novel, safe, and effective treatment option, particularly for underserved populations disproportionately affected by cocaine use.

Infographic summary of Psilocybin in the Treatment of Cocaine Use Disorder: A Randomized Clinical Trial.
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