Randomized Trialhigh evidence
Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy: The OCULUS Randomized Clinical Trial.
JAMA internal medicine·May 1, 2026·PMID 41837981
Why it mattersGLP-1/GIP agonists are widely used, and their effect on gastric emptying raises safety concerns during sedation. This trial provides high-quality evidence to guide periprocedural management, directly informing whether to hold these medications before upper endoscopy.
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