Randomized Trialhigh evidence
Time-of-day immunochemotherapy in non-small cell lung cancer: a randomized phase 3 trial.
Nature medicine·April 1, 2026·PMID 41629425
Why it mattersTiming of immunotherapy infusion is a low-cost, easily implementable factor that may substantially enhance outcomes in NSCLC. This prospective evidence supports considering time-of-day scheduling to optimize treatment efficacy.

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