Meta-Analysishigh evidence
Daily sedation interruption versus no daily sedation interruption for critically ill adults and children requiring invasive mechanical ventilation.
The Cochrane database of systematic reviews·October 7, 2026·PMID 42841340
Why it mattersSedation management in mechanically ventilated patients directly affects ventilator days, ICU complications, and survival. This review provides moderate-certainty evidence that DSI reduces mortality and length of stay without increasing accidental extubation, supporting its use as a safe component of sedation protocols in critical care.
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