Randomized Trialhigh evidence
Emergency Department-Initiated Buprenorphine for Opioid Use Disorder: A Randomized Clinical Trial.
JAMA·March 17, 2026·PMID 41670966
Why it mattersEmergency physicians need evidence on whether a long-acting injectable buprenorphine formulation improves early treatment engagement when initiated in the ED. This trial provides robust data that both approaches yield comparable engagement, but the injectable may offer secondary benefits in craving and illicit use.
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