Cohort Studymoderate evidence
Sex-specific biological aging clocks across organs and omics.
Nature medicine·September 16, 2026·PMID 42749890
Why it mattersBiological age estimation is increasingly used in clinical risk stratification and longevity medicine, but most clocks are trained on sex-pooled data, potentially obscuring sex-specific aging trajectories. This paper demonstrates that organ-specific aging liability and its links to cardiometabolic, endocrine, and mental traits are configured differently in females and males, suggesting that sex-stratified clocks may improve precision in predicting disease and mortality.
The papers that matter, first.
MedLit ranks the medical literature into a specialty feed with concise summaries, evidence-aware triage, and visual takeaways.
§
MedLit · Evidence, Distilled