Randomized Trialmoderate evidence
Topical application of urolithin A activates mitophagy and enhances mitochondrial function to promote skin longevity.
iScience·October 16, 2026·PMID 42866687
Why it mattersSkin aging involves mitochondrial dysfunction and cellular senescence. A topical agent that activates mitophagy could address these mechanisms directly, offering a novel approach to skin rejuvenation and photoprotection.
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