Cohort Studyhigh evidence
Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men.
The Journal of clinical endocrinology and metabolism·June 17, 2025·PMID 39373573
Why it mattersFracture risk assessment in aging men often focuses on testosterone, but this study clarifies that SHBG may be the more clinically relevant biomarker. Recognizing SHBG as a stronger predictor can refine risk stratification and guide monitoring in men at risk for osteoporosis.
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