Randomized Trialhigh evidence
Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial.
Intensive care medicine·July 1, 2026·PMID 42301311
Why it mattersVitamin C has been proposed as a pleiotropic therapy to mitigate post-cardiac arrest syndrome, but this trial provides high-level evidence that high-dose vitamin C not only lacks benefit but may cause harm, directly informing resuscitation and critical care practice.
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