Cohort Studyhigh evidence
Higher Circulating Testosterone Linked to Higher CAD Risk in Men: Mendelian Randomization and Survival Analyses.
The Journal of clinical endocrinology and metabolism·March 17, 2026·PMID 41131989
Why it mattersTestosterone supplementation is increasingly used for sexual and metabolic health, yet cardiovascular safety remains uncertain. This genetic analysis provides evidence that higher endogenous testosterone may causally increase CAD risk in men, highlighting a potential safety concern that warrants attention in clinical practice and future trials.
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