Randomized Trialhigh evidence
Comparison of Extended-Release Buprenorphine Doses for Treating High-Risk Opioid Use: A Randomized Clinical Trial.
JAMA network open·December 1, 2025·PMID 41405885
Why it mattersAs fentanyl dominates the illicit opioid supply, identifying optimal buprenorphine dosing for patients with heavy fentanyl use is critical. This trial provides direct evidence that a higher maintenance dose may improve abstinence in this high-risk subgroup.
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