Regional Citrate Anticoagulation Versus No Anticoagulation During Continuous Renal Replacement Therapy in Critically Ill Patients at High Risk of Bleeding: A Meta-analysis of Randomized Controlled Trials.

Advances in therapy·July 23, 2026·PMID 42490008

Why it matters

For critically ill patients with high bleeding risk requiring CRRT, balancing circuit patency against bleeding complications is a daily challenge. This meta-analysis provides pooled estimates showing RCA improves filter life and reduces clotting without increasing mortality, while potentially lowering major bleeding—though metabolic monitoring is essential.