Randomized Trialhigh evidence
Rapid Initiation of Injection Naltrexone for Opioid Use Disorder: A Stepped-Wedge Cluster Randomized Clinical Trial.
JAMA network open·May 1, 2024·PMID 38717773
Why it mattersThe standard XR-naltrexone initiation requires a prolonged opioid-free period, limiting its use. This rapid protocol nearly doubles successful initiation rates without worsening withdrawal, offering a practical strategy to expand access to this effective relapse-prevention medication.
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