Randomized Trialhigh evidence
Prolonged Continuous Theta Burst Stimulation With Transcranial Magnetic Stimulation Analgesic Effects and Corticospinal Excitability in Chronic Neuropathic Pain: A Randomized Clinical Trial.
Anesthesia and analgesia·August 24, 2026·PMID 42644812
Why it mattersChronic neuropathic pain is often refractory, and rTMS response rates vary. pcTBS offers similar analgesia to 10-Hz rTMS but with substantially shorter session duration, potentially improving feasibility and patient access. The finding that maintenance sessions sustain benefit and DLPFC stimulation helps nonresponders provides a practical treatment algorithm.
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