Cohort Studyhigh evidence
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score.
JAMA·December 16, 2025·PMID 41159833
Why it mattersThe original SOFA score has been unchanged for 30 years and may not reflect modern ICU practices. SOFA-2 offers a data-driven update that better captures current organ dysfunction patterns and mortality risk, potentially improving prognostication and research comparability in critical care.
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