Randomized Trialhigh evidence
Resistance training load does not determine resistance training-induced hypertrophy across upper and lower limbs in healthy young males.
The Journal of physiology·December 31, 2025·PMID 41474371
Why it mattersIt suggests that individual biological factors, not load magnitude, primarily drive hypertrophic response when effort is matched. This informs personalized exercise prescription and shifts focus from load selection to effort and consistency.
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