Randomized Trialhigh evidence
An opioid-withholding human laboratory paradigm during opioid agonist treatment for opioid use disorder and chronic pain: Phase- and dose-dependent effects of cannabidiol.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·May 20, 2026·PMID 42162267
Why it mattersCBD is widely used for pain, but its interaction with opioid agonist treatment is unknown. This study reveals that methadone timing reverses CBD’s analgesic effects, a critical safety and efficacy consideration for patients and clinicians.
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