Randomized Trialhigh evidence
After THA or TKA, aspirin alone was noninferior to rivaroxaban then aspirin for symptomatic VTE at 90 d.
Annals of internal medicine·October 1, 2026·PMID 42832796
Why it mattersPostoperative VTE prophylaxis after joint replacement often involves anticoagulants with higher bleeding risk and cost. Demonstrating aspirin's noninferiority to a rivaroxaban-based regimen could simplify care, reduce bleeding, and lower costs for orthopedic patients.
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