Randomized Trialmoderate evidence
Longitudinal association of dietary spermidine with hepatic function indexes and cardiometabolic traits in older adults with metabolic syndrome.
European journal of nutrition·July 15, 2026·PMID 42455181
Why it mattersSpermidine is a naturally occurring polyamine with emerging evidence for metabolic benefits, but human data are scarce. These findings from a large trial suggest that increasing dietary spermidine may improve liver fat and cardiometabolic risk in a high-risk population, offering a potential nutritional target for managing metabolic syndrome and NAFLD.
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