Meta-Analysishigh evidence
Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
Molecular psychiatry·July 6, 2026·PMID 42410082
Why it mattersL-theanine is widely used as a nootropic and stress-reducing supplement, but clinical evidence has been mixed. This meta-analysis clarifies that its most robust short-term benefit is on attention, not stress or anxiety, which can guide patient counseling and product expectations in cognitive performance and longevity contexts.
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