Basic Sciencemoderate evidence
Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging.
Science (New York, N.Y.)·July 16, 2026·PMID 42462036
Why it mattersAging-related organ decline is linked to a reversible defect in macrophage clearance of senescent neutrophils, driven by EP2 signaling. This mechanism spans multiple tissues and is conserved in humans, offering a potential therapeutic target for age-associated multimorbidity.
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