Randomized Trialhigh evidence

Circadian Rhythm Stabilization App to Prevent Mood Episode Recurrence in Patients With Mood Disorders: A Multicenter, Double-Blind, Sham-Controlled, Randomized Clinical Trial.

The American journal of psychiatry·June 24, 2026·PMID 42337416

Why it matters

Circadian rhythm disruption is a core feature of mood disorders and a target for intervention. This study provides high-level evidence that a scalable, passive-sensing digital tool can meaningfully reduce recurrence, offering a low-burden adjunct to standard care for patients with mood disorders.

Infographic summary of Circadian Rhythm Stabilization App to Prevent Mood Episode Recurrence in Patients With Mood Disorders: A Multicenter, Double-Blind, Sham-Controlled, Randomized Clinical Trial.
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