Basic Sciencemoderate evidence
A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging.
Science advances·June 12, 2026·PMID 42268956
Why it mattersNOX4 loss may explain why aging muscle loses its ability to adapt to exercise, contributing to sarcopenia and metabolic decline. This identifies a molecular target for interventions aimed at preserving muscle function and systemic health in older adults.
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