Randomized Trialhigh evidence
Impact of a strategy using multiplex PCR on targeted antibiotic therapy for patients with suspected ventilator-associated pneumonia or hospital-acquired pneumonia requiring mechanical ventilation: a randomized, single-blind trial.
Intensive care medicine·August 20, 2026·PMID 42622675
Why it mattersRapid pathogen identification could improve antibiotic stewardship in ventilator-associated pneumonia, but clinical benefit has been uncertain. This trial suggests multiplex PCR may not broadly improve early targeted therapy, though it may help when pneumonia is confirmed by culture.
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