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Mapping structural aging across human tissues reveals tissue-specific trajectories and coordinated deterioration.

Nature aging·August 31, 2026·PMID 42675190

Why it matters

Understanding how organ structure changes with age is fundamental to aging biology and longevity medicine. This systematic map of structural aging across 40 tissues provides a reference for identifying early organ-specific aging and potential targets for intervention. The finding that structural aging accelerates at different life stages—such as vascular early and reproductive tissues around menopause—could inform personalized screening and preventive strategies.

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