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Emergency Department Opioid Withdrawal Management Across the Alpha-2 Agonist Adulterated Fentanyl Era in Philadelphia, PA: A Multi-Site Study.
Substance use & addiction journal·July 8, 2026·PMID 42421372
Why it mattersThe emergence of medetomidine in the fentanyl supply is associated with a surge in withdrawal presentations and a marked drop in ED-initiated MOUD, highlighting operational and clinical challenges that emergency and addiction medicine clinicians must navigate.
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