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Glucagon-like peptide 1 receptor agonist use and risk of arthroplasty for knee osteoarthritis: retrospective database analysis.
Regional anesthesia and pain medicine·June 2, 2026·PMID 42229941
Why it mattersKnee osteoarthritis lacks effective disease-modifying therapies, and TKA is a major endpoint. These findings suggest GLP-1 RAs may delay or prevent arthroplasty, offering a potential new avenue for OA management beyond weight loss.
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