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The Divergent Effects of Nicotinamide Riboside and High-Intensity Exercise Training on Skeletal Muscle Epigenetic Aging.
Aging cell·August 1, 2026·PMID 42481916
Why it mattersEpigenetic clocks are emerging biomarkers of biological aging, and interventions that slow or reverse them in muscle could inform longevity strategies. This paper shows that NR and HIIT have opposing effects on muscle epigenetic aging, challenging the assumption that all mitochondrial-targeting interventions uniformly benefit aging clocks.
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