Meta-Analysishigh evidence
In adults with in-hospital cardiac arrest, sodium bicarbonate vs. placebo did not increase sustained ROSC rates.
Annals of internal medicine·October 1, 2026·PMID 42832811
Why it mattersIn-hospital cardiac arrest management frequently includes sodium bicarbonate despite limited evidence. This meta-analysis provides high-level evidence that routine bicarbonate use does not improve ROSC, informing resuscitation protocols and reducing potentially unnecessary interventions.
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