Randomized Trialhigh evidence
Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial.
JAMA·June 11, 2026·PMID 42273960
Why it mattersSodium bicarbonate is widely used during cardiac arrest despite limited evidence. This large RCT provides high-quality data that routine bicarbonate does not improve ROSC or survival, informing resuscitation guidelines and bedside decision-making.
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