Meta-Analysishigh evidence
QTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials.
BMJ (Clinical research ed.)·September 23, 2026·PMID 42778211
Why it mattersQTc prolongation is a key safety concern when prescribing antidepressants, especially in patients with cardiovascular risk factors. This analysis quantifies drug-specific effects and shows no early cardiovascular event signal, informing safer prescribing in cardiology and internal medicine.
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