Randomized Trialhigh evidence
The effects of acute ketone monoester supplementation on brain insulin responsiveness and cognitive performance: Results of a randomized, double-blind, placebo-controlled crossover trial in older men with overweight.
Metabolism: clinical and experimental·June 9, 2026·PMID 42263845
Why it mattersThis study provides mechanistic insight into how nutritional ketosis affects brain insulin signaling and cognitive function in aging, relevant for clinicians interested in metabolic and cognitive health interventions.
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